A marketing authorisation application must be submitted before the deadline indicated on the approval regulation for the active substance with the latest approval date. For example, your product contains substance X and substance Y, which both belong to PT12. If the Approval Regulation for substance X states a deadline of 01/05/2018 and that for substance Y a deadline of 01/11/2018, then your application must be submitted no later than 01/11/2018.